Simulating Molecular Mechanisms of the MDM2-Mediated Regulatory Interactions: A Conformational Selection Model of the MDM2 Lid Dynamics

Por Verkhivker, Gennady M.
Publicado em 2012

Hierarchical Modeling of Activation Mechanisms in the ABL and EGFR Kinase Domains: Thermodynamic and Mechanistic Catalysts of Kinase Activation by Cancer Mutations

Por Dixit, Anshuman, Verkhivker, Gennady M.
Publicado em 2009

Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases

Por Dixit, Anshuman, Verkhivker, Gennady M.
Publicado em 2011

The Energy Landscape Analysis of Cancer Mutations in Protein Kinases

Por Dixit, Anshuman, Verkhivker, Gennady M.
Publicado em 2011

Probing Molecular Mechanisms of the Hsp90 Chaperone: Biophysical Modeling Identifies Key Regulators of Functional Dynamics

Por Dixit, Anshuman, Verkhivker, Gennady M.
Publicado em 2012

Differential Modulation of Functional Dynamics and Allosteric Interactions in the Hsp90-Cochaperone Complexes with p23 and Aha1: A Computational Study

Por Blacklock, Kristin, Verkhivker, Gennady M.
Publicado em 2013

Allosteric Regulation of the Hsp90 Dynamics and Stability by Client Recruiter Cochaperones: Protein Structure Network Modeling

Por Blacklock, Kristin, Verkhivker, Gennady M.
Publicado em 2014

Structure-Functional Prediction and Analysis of Cancer Mutation Effects in Protein Kinases

Por Dixit, Anshuman, Verkhivker, Gennady M.
Publicado em 2014

Computational Modeling of Allosteric Regulation in the Hsp90 Chaperones: A Statistical Ensemble Analysis of Protein Structure Networks and Allosteric Communications

Por Blacklock, Kristin, Verkhivker, Gennady M.
Publicado em 2014

Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions...

Por Tse, Amanda, Verkhivker, Gennady M.
Publicado no PLoS One (2015)

Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins

Por Stetz, Gabrielle, Verkhivker, Gennady M.
Publicado no PLoS One (2015)

Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networ...

Por Tse, Amanda, Verkhivker, Gennady M.
Publicado no PLoS One (2016)

Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communicatio...

Por Stetz, Gabrielle, Verkhivker, Gennady M.
Publicado no PLoS Comput Biol (2017)

Structure-Based Network Analysis of Activation Mechanisms in the ErbB Family of Receptor Tyrosine Kinases: The Regulatory Spine Residues Are Global Mediators of Structural Stabilit...

Por James, Kevin A., Verkhivker, Gennady M.
Publicado no PLoS One (2014)

Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the...

Por Stetz, Gabrielle, Tse, Amanda, Verkhivker, Gennady M.
Publicado no PLoS One (2017)

Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots o...

Por Czemeres, Josh, Buse, Kurt, Verkhivker, Gennady M.
Publicado no PLoS One (2017)

Dissecting Structure-Encoded Determinants of Allosteric Cross-Talk between Post-Translational Modification Sites in the Hsp90 Chaperones

Por Stetz, Gabrielle, Tse, Amanda, Verkhivker, Gennady M.
Publicado no Sci Rep (2018)

Integration of Random Forest Classifiers and Deep Convolutional Neural Networks for Classification and Biomolecular Modeling of Cancer Driver Mutations

Por Agajanian, Steve, Oluyemi, Odeyemi, Verkhivker, Gennady M.
Publicado no Front Mol Biosci (2019)

Computational intelligence methods for bioinformatics and biostatistics 5th International Meeting, CIBB 2008 Vietri sul Mare, Italy, October 3-4, 2008 : revised selected papers /

Por CIBB 2008, Masulli, Francesco., Tagliaferri, Roberto., Verkhivker, Gennady M.
Publicado em 2009

Allosteric Regulation at the Crossroads of New Technologies: Multiscale Modeling, Networks, and Machine Learning

Por Verkhivker, Gennady M., Agajanian, Steve, Hu, Guang, Tao, Peng
Publicado no Front Mol Biosci (2020)