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Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains

A fundamental role of the Hsp90 and Cdc37 chaperones in mediating conformational development and activation of diverse protein kinase clients is essential in signal transduction. There has been increasing evidence that the Hsp90-Cdc37 system executes its chaperoning duties by recognizing conformatio...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Czemeres, Josh, Buse, Kurt, Verkhivker, Gennady M.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739471/
https://ncbi.nlm.nih.gov/pubmed/29267381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190267
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