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Dissecting Structure-Encoded Determinants of Allosteric Cross-Talk between Post-Translational Modification Sites in the Hsp90 Chaperones

Post-translational modifications (PTMs) represent an important regulatory instrument that modulates structure, dynamics and function of proteins. The large number of PTM sites in the Hsp90 proteins that are scattered throughout different domains indicated that synchronization of multiple PTMs throug...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Stetz, Gabrielle, Tse, Amanda, Verkhivker, Gennady M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932063/
https://ncbi.nlm.nih.gov/pubmed/29720613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25329-4
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