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The Energy Landscape Analysis of Cancer Mutations in Protein Kinases

The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present study, we combined computer simulations and the energy landscape analysis of...

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Autores principales: Dixit, Anshuman, Verkhivker, Gennady M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188581/
https://ncbi.nlm.nih.gov/pubmed/21998754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026071
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