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Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways
The recent studies have revealed that most BRAF inhibitors can paradoxically induce kinase activation by promoting dimerization and enzyme transactivation. Despite rapidly growing number of structural and functional studies about the BRAF dimer complexes, the molecular basis of paradoxical activatio...
में बचाया:
में प्रकाशित: | PLoS One |
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मुख्य लेखकों: | , |
स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
Public Library of Science
2016
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5115767/ https://ncbi.nlm.nih.gov/pubmed/27861609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166583 |
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