Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

TRAP1 (TNF receptor-associated protein), a member of the HSP90 chaperone family, is found predominantly in mitochondria. TRAP1 is broadly considered to be an anticancer molecular target. However, current inhibitors cannot distinguish between HSP90 and TRAP1, making their utility as probes of TRAP1-s...

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Detalhes bibliográficos
Main Authors: Yoshida, Soichiro, Tsutsumi, Shinji, Muhlebach, Guillaume, Sourbier, Carole, Lee, Min-Jung, Lee, Sunmin, Vartholomaiou, Evangelia, Tatokoro, Manabu, Beebe, Kristin, Miyajima, Naoto, Mohney, Robert P., Chen, Yang, Hasumi, Hisashi, Xu, Wanping, Fukushima, Hiroshi, Nakamura, Ken, Koga, Fumitaka, Kihara, Kazunori, Trepel, Jane, Picard, Didier, Neckers, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637790/
https://ncbi.nlm.nih.gov/pubmed/23564345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220659110
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