Swe1(Wee1)-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

Swe1 (Saccharomyces WEE1), the only “true” tyrosine kinase in budding yeast, is an Hsp90 client protein. Here we show that Swe1(Wee1) phosphorylates a conserved tyrosine residue (Y24 in yeast Hsp90 and Y38 in human Hsp90α) in the N-domain of Hsp90. Phosphorylation is cell cycle-associated and modula...

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Detalhes bibliográficos
Main Authors: Mollapour, Mehdi, Tsutsumi, Shinji, Donnelly, Alison C., Beebe, Kristin, Tokita, Mari J., Lee, Min-Jung, Lee, Sunmin, Morra, Giulia, Bourboulia, Dimitra, Scroggins, Bradley T., Colombo, Giorgio, Blagg, Brian S., Panaretou, Barry, Stetler-Stevenson, William G., Trepel, Jane B., Piper, Peter W., Prodromou, Chrisostomos, Pearl, Laurence H., Neckers, Len
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824606/
https://ncbi.nlm.nih.gov/pubmed/20159553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.005
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