Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics

Autor Smrcka, Alan V.
Vydáno 2013

Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes

Autor Smrcka, Alan V.
Vydáno v J Cardiovasc Pharmacol (2015)

Understanding Molecular Recognition by G protein βγ Subunits on the Path to Pharmacological Targeting

Autor Lin, Yuan, Smrcka, Alan V.
Vydáno 2011

Activated heterotrimeric G protein α(i) subunits inhibit Rap-dependent cell adhesion and promote cell migration

Autor To, Jesi Y., Smrcka, Alan V.
Vydáno v J Biol Chem (2018)

G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling

Autor Smrcka, Alan V., Fisher, Isaac
Vydáno v Cell Mol Life Sci (2019)

HPLC Separation and Indirect Ultraviolet Detection of Phosphorylated Sugars

Autor Smrcka, Alan V., Jensen, Richard G.
Vydáno 1988

Phenotypical Temperature Adaptation of Protein Turnover in Desert Annuals

Autor Smrcka, Alan V., Szarek, Stan R.
Vydáno 1986

Discovery of Ligands for βγ Subunits from Phage-Displayed Peptide Libraries

Autor Smrcka, Alan V., Scott, Jamie K.
Vydáno 2002

Targeting G protein-coupled receptor signalling by blocking G proteins

Autor Campbell, Adrian P., Smrcka, Alan V.
Vydáno v Nat Rev Drug Discov (2018)

WDR26 Functions as a Scaffolding Protein to Promote Gβγ-mediated Phospholipase C β2 (PLCβ2) Activation in Leukocytes

Autor Sun, Zhizeng, Smrcka, Alan V., Chen, Songhai
Vydáno 2013

Conformational flexibility and binding interactions of the G protein βγ heterodimer

Autor Park, Min-Sun, Smrcka, Alan V., Stern, Harry
Vydáno 2011

A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis

Autor Surve, Chinmay R., Lehmann, David, Smrcka, Alan V.
Vydáno 2014

Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.

Autor Kelley, Grant G, Reks, Sarah E, Smrcka, Alan V
Vydáno 2004

MECHANISTIC PATHWAYS AND BIOLOGICAL ROLES FOR RECEPTOR-INDEPENDENT ACTIVATORS OF G-PROTEIN SIGNALING

Autor Blumer, Joe B., Smrcka, Alan V., Lanier, S.M.
Vydáno 2006

A Novel Gβγ-Subunit Inhibitor Selectively Modulates μ-Opioid-Dependent Antinociception and Attenuates Acute Morphine-Induced Antinociceptive Tolerance and Dependence

Autor Mathews, Jennifer L., Smrcka, Alan V., Bidlack, Jean M.
Vydáno 2008

G Protein βγ Subunits as Targets for Small Molecule Therapeutic Development

Autor Smrcka, Alan V., Lehmann, David M., Dessal, Axel L.
Vydáno 2008

Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits

Autor Kamal, Fadia A., Smrcka, Alan V., Blaxall, Burns C.
Vydáno 2011

Direct-reversible binding of small molecules to G protein βγ subunits

Autor Seneviratne, AMPB, Burroughs, Michael, Giralt, Ernest, Smrcka, Alan V.
Vydáno 2011

Role of phospholipase Cε in physiological phosphoinositide signaling networks

Autor Smrcka, Alan V., Brown, Joan Heller, Holz, George G.
Vydáno 2012

Rational Design of a Selective Covalent Modifier of G Protein βγ Subunits

Autor Dessal, Axel L., Prades, Roger, Giralt, Ernest, Smrcka, Alan V.
Vydáno 2011