Secrets of insulin and IGF-1 regulation of insulin secretion revealed.

Por Shepherd, Peter R
Publicado em 2004

Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA binding.

Por O'Rourke, Lisa, Shepherd, Peter R
Publicado em 2002

Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase

Por Dickson, James M. J., Lee, Woo-Jeong, Shepherd, Peter R., Buchanan, Christina M.
Publicado em 2013

Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo

Por Foukas, Lazaros C., Beeton, Caroline A., Jensen, Jorgen, Phillips, Wayne A., Shepherd, Peter R.
Publicado em 2004

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

Por Smith, Greg C., Ong, Wee Kiat, Rewcastle, Gordon W., Kendall, Jackie D., Han, Weiping, Shepherd, Peter R.
Publicado em 2012

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation

Por Liu, Jing, Xu, Aimin, Lam, Karen Siu-Ling, Wong, Nai-Sum, Chen, Jie, Shepherd, Peter R, Wang, Yu
Publicado em 2013

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity

Por Buchanan, Christina M., Dickson, James M. J., Lee, Woo-Jeong, Guthridge, Mark A., Kendall, Jackie D., Shepherd, Peter R.
Publicado em 2013

Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth

Por Sweetlove, Melanie, Wrightson, Emma, Kolekar, Sharada, Rewcastle, Gordon W., Baguley, Bruce C., Shepherd, Peter R., Jamieson, Stephen M. F.
Publicado no Front Oncol (2015)

A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization

Por Sorrenson, Brie, Cognard, Emmanuelle, Lee, Kathryn L., Dissanayake, Waruni C., Fu, Yanyun, Han, Weiping, Hughes, William E., Shepherd, Peter R.
Publicado no J Biol Chem (2016)

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

Por Zheng, Zhaohua, Amran, Syazwani I., Zhu, Jiuxiang, Schmidt-Kittler, Oleg, Kinzler, Kenneth W., Vogelstein, Bert, Shepherd, Peter R., Thompson, Philip E., Jennings, Ian G.
Publicado em 2012

Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

Por Kim, Ji Eun, Stones, Clare, Joseph, Wayne R, Leung, Euphemia, Finlay, Graeme J, Shelling, Andrew N, Phillips, Wayne A, Shepherd, Peter R, Baguley, Bruce C
Publicado em 2012

Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities

Por Lam, Janice B. B., Chow, Kim H. M., Xu, Aimin, Lam, Karen S. L., Liu, Jing, Wong, Nai-Sum, Moon, Randall T., Shepherd, Peter R., Cooper, Garth J. S., Wang, Yu
Publicado em 2009

Correction: Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities

Por Lam, Janice B. B., Chow, Kim H. M., Xu, Aimin, Lam, Karen S. L., Liu, Jing, Wong, Nai-Sum, Moon, Randall T., Shepherd, Peter R., Cooper, Garth J. S., Wang, Yu
Publicado em 2009

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Por Chaussade, Claire, Rewcastle, Gordon W., Kendall, Jackie D., Denny, William A., Cho, Kitty, Grønning, Line M., Chong, Mei Ling, Anagnostou, Sasha H., Jackson, Shaun P., Daniele, Nathalie, Shepherd, Peter R.
Publicado em 2007

Leptin Rapidly Improves Glucose Homeostasis in Obese Mice by Increasing Hypothalamic Insulin Sensitivity

Por Koch, Christiane, Augustine, Rachael A., Steger, Juliane, Ganjam, Goutham K., Benzler, Jonas, Pracht, Corinna, Lowe, Chrishanthi, Schwartz, Michael W., Shepherd, Peter R., Anderson, Greg M., Grattan, David R., Tups, Alexander
Publicado em 2010

NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand

Por Jones, Angela M., Ferguson, Peter, Gardner, Jacqui, Rooker, Serena, Sutton, Tim, Ahn, Antonio, Chatterjee, Aniruddha, Bickley, Vivienne M., Sarwar, Makhdoom, Emanuel, Patrick, Kenwright, Diane, Shepherd, Peter R., Eccles, Michael R.
Publicado no Oncotarget (2016)

Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes

Por Chowdhury, Md. Kamrul Hasan, Turner, Nigel, Bentley, Nicholas L., Das, Abhirup, Wu, Lindsay E., Richani, Dulama, Bustamante, Sonia, Gilchrist, Robert B., Morris, Margaret J., Shepherd, Peter R., Smith, Greg C.
Publicado no Sci Rep (2017)

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Por Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.
Publicado em 2004

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

Por Jamieson, Stephen, Flanagan, Jack U., Kolekar, Sharada, Buchanan, Christina, Kendall, Jackie D., Lee, Woo-Jeong, Rewcastle, Gordon W., Denny, William A., Singh, Ripudaman, Dickson, James, Baguley, Bruce C., Shepherd, Peter R.
Publicado em 2011

Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism

Por Benzler, Jonas, Ganjam, Goutham K., Krüger, Manon, Pinkenburg, Olaf, Kutschke, Maria, Stöhr, Sigrid, Steger, Juliane, Koch, Christiane E., Ölkrug, Rebecca, Schwartz, Michael W., Shepherd, Peter R., Grattan, David R., Tups, Alexander
Publicado em 2012