A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted on chromosome 10), amplifications of PIK3CA and mutations in two distinct regions of the PIK3CA gene. This suggests drugs targeting PI3K, an...

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Hlavní autoři: Jamieson, Stephen, Flanagan, Jack U., Kolekar, Sharada, Buchanan, Christina, Kendall, Jackie D., Lee, Woo-Jeong, Rewcastle, Gordon W., Denny, William A., Singh, Ripudaman, Dickson, James, Baguley, Bruce C., Shepherd, Peter R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174055/
https://ncbi.nlm.nih.gov/pubmed/21668414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110502
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