A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted on chromosome 10), amplifications of PIK3CA and mutations in two distinct regions of the PIK3CA gene. This suggests drugs targeting PI3K, an...

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Detalhes bibliográficos
Main Authors: Jamieson, Stephen, Flanagan, Jack U., Kolekar, Sharada, Buchanan, Christina, Kendall, Jackie D., Lee, Woo-Jeong, Rewcastle, Gordon W., Denny, William A., Singh, Ripudaman, Dickson, James, Baguley, Bruce C., Shepherd, Peter R.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174055/
https://ncbi.nlm.nih.gov/pubmed/21668414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110502
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