Importin-11 keeps PTEN safe from harm

par Leslie, Nick R.
Publié dans J Cell Biol (2017)

PTEN function: how normal cells control it and tumour cells lose it

par Leslie, Nick R., Downes, C. Peter
Publié 2004

Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases

par Leslie, Nick R, McLennan, Alexander G, Safrany, Stephen T
Publié 2002

PtdIns(3,4,5)P(3)-Dependent and -Independent Roles for PTEN in the Control of Cell Migration

par Leslie, Nick R., Yang, Xuesong, Downes, C. Peter, Weijer, Cornelis J.
Publié 2007

Mechanism of Activation of PKB/Akt by the Protein Phosphatase Inhibitor Calyculin A

par Pozuelo-Rubio, Mercedes, Leslie, Nick R., Murphy, Jane, MacKintosh, Carol
Publié 2010

PTEN is destabilized by phosphorylation on Thr(366)

par Maccario, Helene, Perera, Nevin M., Davidson, Lindsay, Downes, C. Peter, Leslie, Nick R.
Publié 2007

Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress

par Maccario, Helene, Perera, Nevin M., Gray, Alexander, Downes, C. Peter, Leslie, Nick R.
Publié 2010

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

par Leslie, Nick R., Bennett, Deborah, Lindsay, Yvonne E., Stewart, Hazel, Gray, Alex, Downes, C.Peter
Publié 2003

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.

par Walker, Steven M, Leslie, Nick R, Perera, Nevin M, Batty, Ian H, Downes, C Peter
Publié 2004

Loss of PTEN selectively desensitises upstream IGF1 and insulin signalling

par Lackey, Joe, Barnett, Jill, Davidson, Lindsay, Batty, Ian H., Leslie, Nick R., Downes, C. Peter
Publié 2007

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1

par Berglund, Fredrik, Weerasinghe, Nimmi R., Davidson, Lindsay, Lim, Joseph C., Eickholt, Britta J., Leslie, Nick R.
Publié 2012

Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy.

par Watt, Stephen A, Kimber, Wendy A, Fleming, Ian N, Leslie, Nick R, Downes, C Peter, Lucocq, John M
Publié 2004

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells

par Ning, Ke, Miller, Lisa C, Laidlaw, Hilary A, Burgess, Laura A, Perera, Nevin M, Downes, C Peter, Leslie, Nick R, Ashford, Michael LJ
Publié 2006

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

par Davidson, Lindsay, Maccario, Helene, Perera, Nevin M., Yang, Xuesong, Spinelli, Laura, Tibarewal, Priyanka, Glancy, Ben, Gray, Alex, Weijer, Cornelis J., Downes, C. Peter, Leslie, Nick R.
Publié 2009

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

par Silva, Ana, Yunes, J. Andrés, Cardoso, Bruno A., Martins, Leila R., Jotta, Patrícia Y., Abecasis, Miguel, Nowill, Alexandre E., Leslie, Nick R., Cardoso, Angelo A., Barata, Joao T.
Publié 2008

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

par Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.
Publié 2004

Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental de...

par Wong, Chi Wai, Or, Penelope Mei Yu, Wang, Yubing, Li, Lisha, Li, Jing, Yan, Mingfei, Cao, Ye, Luk, Ho Ming, Tong, Tony Ming For, Leslie, Nick R., Lo, Ivan Fai‐Man, Choy, Kwong Wai, Chan, Andrew Man Lok
Publié dans Autism Res (2018)

C1-Ten Is a Protein Tyrosine Phosphatase of Insulin Receptor Substrate 1 (IRS-1), Regulating IRS-1 Stability and Muscle Atrophy

par Koh, Ara, Lee, Mi Nam, Yang, Yong Ryoul, Jeong, Heeyoon, Ghim, Jaewang, Noh, Jeongeun, Kim, Jaeyoon, Ryu, Dongryeol, Park, Sehoon, Song, Parkyong, Koo, Seung-Hoi, Leslie, Nick R., Berggren, Per-Olof, Choi, Jang Hyun, Suh, Pann-Ghill, Ryu, Sung Ho
Publié 2013

MC1R is a Potent Regulator of PTEN after UV Exposure in Melanocytes

par Cao, Juxiang, Wan, Lixin, Hacker, Elke, Dai, Xiangpeng, Lenna, Stefania, Jimenez-Cervantes, Celia, Wang, Yongjun, Leslie, Nick R., Xu, George X., Widlund, Hans R., Ryu, Byungwoo, Alani, Rhoda M., Dutton-Regester, Ken, Goding, Colin R., Hayward, Nicholas K., Wei, Wenyi, Cui, Rutao
Publié 2013

Cross Talk between the Akt and p38α Pathways in Macrophages Downstream of Toll-Like Receptor Signaling

par McGuire, Victoria A., Gray, Alexander, Monk, Claire E., Santos, Susana G., Lee, Keunwook, Aubareda, Anna, Crowe, Jonathan, Ronkina, Natalia, Schwermann, Jessica, Batty, Ian H., Leslie, Nick R., Dean, Jonathan L. E., O'Keefe, Stephen J., Boothby, Mark, Gaestel, Matthias, Arthur, J. Simon C.
Publié 2013