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Mechanism of Activation of PKB/Akt by the Protein Phosphatase Inhibitor Calyculin A
The protein phosphatase inhibitor calyculin A activates PKB/Akt to ~50% of the activity induced by insulin-like growth factor 1 (IGF1) in HeLa cells promoting an evident increased phosphorylation of Ser473 despite the apparent lack of Thr308 phosphorylation of PKB. Nevertheless, calyculin A-induced...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Humana Press Inc
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627045/ https://ncbi.nlm.nih.gov/pubmed/20717744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12013-010-9101-4 |
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