Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy.

PtdIns(3,4) P (2), a breakdown product of the lipid second messenger PtdIns(3,4,5) P (3), is a key signalling molecule in pathways controlling various cellular events. Cellular levels of PtdIns(3,4) P (2) are elevated upon agonist stimulation, mediating downstream signalling pathways by recruiting p...

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Detalhes bibliográficos
Main Authors: Watt, Stephen A, Kimber, Wendy A, Fleming, Ian N, Leslie, Nick R, Downes, C Peter, Lucocq, John M
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223916/
https://ncbi.nlm.nih.gov/pubmed/14604433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031397
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