Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.

Phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] and its immediate breakdown product PtdIns(3,4)P(2) function as second messengers in growth factor- and insulin-induced signalling pathways. One of the ways that these 3-phosphoinositides are known to regulate downstream signalling events...

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Detalhes bibliográficos
Main Authors: Thomas, C C, Dowler, S, Deak, M, Alessi, D R, van Aalten, D M
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222060/
https://ncbi.nlm.nih.gov/pubmed/11513726
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