Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

Protein kinase B (PKB/Akt) is a key regulator of cell growth, proliferation and metabolism. It possesses an N-terminal pleckstrin homology (PH) domain that interacts with equal affinity with the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2, generated through insulin and growth factor-mediated...

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Detalhes bibliográficos
Main Authors: Milburn, Christine C, Deak, Maria, Kelly, Sharon M, Price, Nick C, Alessi, Dario R, Van Aalten, Daan M F
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223737/
https://ncbi.nlm.nih.gov/pubmed/12964941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031229
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