Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell metabolism, cell survival, and apoptosis. Phosphatidylinositol-3,4,5-trisphosphate (PIP3), the product of PI3K activity and a key signaling molecule, acts by recruiting pleckstrin-homology (PH) domain-containing protein...

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Detalhes bibliográficos
Main Authors: Miao, Benchun, Skidan, Igor, Yang, Jinsheng, Lugovskoy, Alexey, Reibarkh, Mikhail, Long, Kai, Brazell, Tres, Durugkar, Kulbhushan A., Maki, Jenny, Ramana, C. V., Schaffhausen, Brian, Wagner, Gerhard, Torchilin, Vladimir, Yuan, Junying, Degterev, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993381/
https://ncbi.nlm.nih.gov/pubmed/21041639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004522107
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