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The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour-suppressor protein is a phosphoinositide 3-phosphatase which antagonizes phosphoinositide 3-kinase-dependent signalling by dephosphorylating PtdIns(3,4,5)P3. Most tumour-derived point mutations of PTEN induce a loss of funct...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224073/ https://ncbi.nlm.nih.gov/pubmed/14711368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031839 |
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