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Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo
One potentially important mechanism for regulating class Ia phosphoinositide 3-kinase (PI 3-kinase) activity is autophosphorylation of the p85α adapter subunit on Ser608 by the intrinsic protein kinase activity of the p110 catalytic subunit, as this downregulates the lipid kinase activity in vitro....
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC321424/ https://ncbi.nlm.nih.gov/pubmed/14729945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.3.966-975.2004 |
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