Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Recent genetic knock-in and pharmacological approaches have suggested that, of class IA PI3Ks (phosphatidylinositol 3-kinases), it is the p110α isoform (PIK3CA) that plays the predominant role in insulin signalling. We have used isoform-selective inhibitors of class IA PI3K to dissect further the ro...

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Bibliografske podrobnosti
Main Authors: Chaussade, Claire, Rewcastle, Gordon W., Kendall, Jackie D., Denny, William A., Cho, Kitty, Grønning, Line M., Chong, Mei Ling, Anagnostou, Sasha H., Jackson, Shaun P., Daniele, Nathalie, Shepherd, Peter R.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896275/
https://ncbi.nlm.nih.gov/pubmed/17362206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070003
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