A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation

le Nelson, Erik A., Sharma, Sreenath V., Settleman, Jeffrey, Frank, David A.
Foilsithe 2011

A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes

le Sharma, Sreenath V., Gajowniczek, Patrycja, Way, Inna, Lee, Diana, Jiang, Jane, Yuza, Yuki, Classon, Marie, Haber, Daniel A., Settleman, Jeffrey
Foilsithe 2006

Reduced erlotinib sensitivity of EGFR mutant non-small cell lung cancer following cisplatin exposure: A cell culture model of second-line erlotinib treatment

le Chin, Tan Min, Quinlan, Margaret P., Singh, Anurag, Sequist, Lecia V., Lynch, Thomas J., Haber, Daniel A., Sharma, Sreenath V., Settleman, Jeffrey
Foilsithe 2008

A Structure-guided Approach to Creating Covalent FGFR Inhibitors

le Zhou, Wenjun, Hur, Wooyoung, McDermott, Ultan, Dutt, Amit, Xian, Wa, Picarro, Scott B., Zhang, Jianming, Sharma, Sreenath V., Brugge, Joan, Meyerson, Matthew, Settleman, Jeffrey, Gray, Nathanael S.
Foilsithe 2010

Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe

le Galimberti, Fabrizio, Thompson, Sarah L., Liu, Xi, Li, Hua, Memoli, Vincent, Green, Simon R., DiRenzo, James, Greninger, Patricia, Sharma, Sreenath V., Settleman, Jeff, Compton, Duane A., Dmitrovsky, Ethan
Foilsithe 2009

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

le Montagut, Clara, Sharma, Sreenath V., Shioda, Toshi, McDermott, Ultan, Ulman, Matthew, Ulkus, Lindsey E., Dias-Santagata, Dora, Stubbs, Hannah, Lee, Diana Y., Singh, Anurag, Drew, Lisa, Haber, Daniel A., Settleman, Jeffrey
Foilsithe 2008

Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma

le Plentz, Ruben, Park, Ji-Sun, Rhim, Andrew D., Abravanel, Daniel, Hezel, Aram F., Sharma, Sreenath V., Gurumurthy, Sushma, Deshpande, Vikram, Kenific, Candia, Settleman, Jeffrey, Majumder, Pradip K., Stanger, Ben Z., Bardeesy, Nabeel
Foilsithe 2009

A chromatin-mediated reversible drug tolerant state in cancer cell subpopulations

le Sharma, Sreenath V., Lee, Diana Y., Li, Bihua, Quinlan, Margaret P., Takahashi, Fumiyuki, Maheswaran, Shyamala, McDermott, Ultan, Azizian, Nancy, Zou, Lee, Fischbach, Michael A., Wong, Kwok-Kin, Brandstetter, Kathleyn, Wittner, Ben, Ramaswamy, Sridhar, Classon, Marie, Settleman, Jeff
Foilsithe 2010

Ligand-dependent PDGF receptor-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGF receptor kinase inhibitors

le McDermott, Ultan, Ames, Rachel Y., Iafrate, A. John, Maheswaran, Shyamala, Stubbs, Hannah, Greninger, Patricia, McCutcheon, Kaitlin, Milano, Randy, Tam, Angela, Lee, Diana Y., Lucien, Laury, Brannigan, Brian W., Ulkus, Lindsey E., Ma, Xiao-Jun, Erlander, Mark G., Haber, Daniel A., Sharma, Sreenath V., Settleman, Jeffrey
Foilsithe 2009

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

le Kwak, Eunice L., Sordella, Raffaella, Bell, Daphne W., Godin-Heymann, Nadia, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Driscoll, David R., Fidias, Panos, Lynch, Thomas J., Rabindran, Sridhar K., McGinnis, John P., Wissner, Allan, Sharma, Sreenath V., Isselbacher, Kurt J., Settleman, Jeffrey, Haber, Daniel A.
Foilsithe 2005

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

le McDermott, Ultan, Sharma, Sreenath V., Dowell, Lori, Greninger, Patricia, Montagut, Clara, Lamb, Jennifer, Archibald, Heidi, Raudales, Raul, Tam, Angela, Lee, Diana, Rothenberg, S. Michael, Supko, Jeffrey G., Sordella, Raffaella, Ulkus, Lindsey E., Iafrate, A. John, Maheswaran, Shyamala, Njauw, Ching Ni, Tsao, Hensin, Drew, Lisa, Hanke, Jeff H., Ma, Xiao-Jun, Erlander, Mark G., Gray, Nathanael S., Haber, Daniel A., Settleman, Jeffrey
Foilsithe 2007

Systematic identification of genomic markers of drug sensitivity in cancer cells

le Garnett, Mathew J., Edelman, Elena J., Heidorn, Sonja J., Greenman, Chris D., Dastur, Anahita, Lau, King Wai, Greninger, Patricia, Thompson, I. Richard, Luo, Xi, Soares, Jorge, Liu, Qingsong, Iorio, Francesco, Surdez, Didier, Chen, Li, Milano, Randy J., Bignell, Graham R., Tam, Ah T., Davies, Helen, Stevenson, Jesse A., Barthorpe, Syd, Lutz, Stephen R., Kogera, Fiona, Lawrence, Karl, McLaren-Douglas, Anne, Mitropoulos, Xeni, Mironenko, Tatiana, Thi, Helen, Richardson, Laura, Zhou, Wenjun, Jewitt, Frances, Zhang, Tinghu, O’Brien, Patrick, Boisvert, Jessica L., Price, Stacey, Hur, Wooyoung, Yang, Wanjuan, Deng, Xianming, Butler, Adam, Choi, Hwan Geun, Chang, Jae Won, Baselga, Jose, Stamenkovic, Ivan, Engelman, Jeffrey A., Sharma, Sreenath V., Delattre, Olivier, Saez-Rodriguez, Julio, Gray, Nathanael S., Settleman, Jeffrey, Futreal, P. Andrew, Haber, Daniel A., Stratton, Michael R., Ramaswamy, Sridhar, McDermott, Ultan, Benes, Cyril H.
Foilsithe 2012