A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation

Por Nelson, Erik A., Sharma, Sreenath V., Settleman, Jeffrey, Frank, David A.
Publicado em 2011

A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes

Por Sharma, Sreenath V., Gajowniczek, Patrycja, Way, Inna, Lee, Diana, Jiang, Jane, Yuza, Yuki, Classon, Marie, Haber, Daniel A., Settleman, Jeffrey
Publicado em 2006

Reduced erlotinib sensitivity of EGFR mutant non-small cell lung cancer following cisplatin exposure: A cell culture model of second-line erlotinib treatment

Por Chin, Tan Min, Quinlan, Margaret P., Singh, Anurag, Sequist, Lecia V., Lynch, Thomas J., Haber, Daniel A., Sharma, Sreenath V., Settleman, Jeffrey
Publicado em 2008

A Structure-guided Approach to Creating Covalent FGFR Inhibitors

Por Zhou, Wenjun, Hur, Wooyoung, McDermott, Ultan, Dutt, Amit, Xian, Wa, Picarro, Scott B., Zhang, Jianming, Sharma, Sreenath V., Brugge, Joan, Meyerson, Matthew, Settleman, Jeffrey, Gray, Nathanael S.
Publicado em 2010

Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe

Por Galimberti, Fabrizio, Thompson, Sarah L., Liu, Xi, Li, Hua, Memoli, Vincent, Green, Simon R., DiRenzo, James, Greninger, Patricia, Sharma, Sreenath V., Settleman, Jeff, Compton, Duane A., Dmitrovsky, Ethan
Publicado em 2009

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

Por Montagut, Clara, Sharma, Sreenath V., Shioda, Toshi, McDermott, Ultan, Ulman, Matthew, Ulkus, Lindsey E., Dias-Santagata, Dora, Stubbs, Hannah, Lee, Diana Y., Singh, Anurag, Drew, Lisa, Haber, Daniel A., Settleman, Jeffrey
Publicado em 2008

Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma

Por Plentz, Ruben, Park, Ji-Sun, Rhim, Andrew D., Abravanel, Daniel, Hezel, Aram F., Sharma, Sreenath V., Gurumurthy, Sushma, Deshpande, Vikram, Kenific, Candia, Settleman, Jeffrey, Majumder, Pradip K., Stanger, Ben Z., Bardeesy, Nabeel
Publicado em 2009

A chromatin-mediated reversible drug tolerant state in cancer cell subpopulations

Por Sharma, Sreenath V., Lee, Diana Y., Li, Bihua, Quinlan, Margaret P., Takahashi, Fumiyuki, Maheswaran, Shyamala, McDermott, Ultan, Azizian, Nancy, Zou, Lee, Fischbach, Michael A., Wong, Kwok-Kin, Brandstetter, Kathleyn, Wittner, Ben, Ramaswamy, Sridhar, Classon, Marie, Settleman, Jeff
Publicado em 2010

Ligand-dependent PDGF receptor-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGF receptor kinase inhibitors

Por McDermott, Ultan, Ames, Rachel Y., Iafrate, A. John, Maheswaran, Shyamala, Stubbs, Hannah, Greninger, Patricia, McCutcheon, Kaitlin, Milano, Randy, Tam, Angela, Lee, Diana Y., Lucien, Laury, Brannigan, Brian W., Ulkus, Lindsey E., Ma, Xiao-Jun, Erlander, Mark G., Haber, Daniel A., Sharma, Sreenath V., Settleman, Jeffrey
Publicado em 2009

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

Por Kwak, Eunice L., Sordella, Raffaella, Bell, Daphne W., Godin-Heymann, Nadia, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Driscoll, David R., Fidias, Panos, Lynch, Thomas J., Rabindran, Sridhar K., McGinnis, John P., Wissner, Allan, Sharma, Sreenath V., Isselbacher, Kurt J., Settleman, Jeffrey, Haber, Daniel A.
Publicado em 2005

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

Por McDermott, Ultan, Sharma, Sreenath V., Dowell, Lori, Greninger, Patricia, Montagut, Clara, Lamb, Jennifer, Archibald, Heidi, Raudales, Raul, Tam, Angela, Lee, Diana, Rothenberg, S. Michael, Supko, Jeffrey G., Sordella, Raffaella, Ulkus, Lindsey E., Iafrate, A. John, Maheswaran, Shyamala, Njauw, Ching Ni, Tsao, Hensin, Drew, Lisa, Hanke, Jeff H., Ma, Xiao-Jun, Erlander, Mark G., Gray, Nathanael S., Haber, Daniel A., Settleman, Jeffrey
Publicado em 2007

Systematic identification of genomic markers of drug sensitivity in cancer cells

Por Garnett, Mathew J., Edelman, Elena J., Heidorn, Sonja J., Greenman, Chris D., Dastur, Anahita, Lau, King Wai, Greninger, Patricia, Thompson, I. Richard, Luo, Xi, Soares, Jorge, Liu, Qingsong, Iorio, Francesco, Surdez, Didier, Chen, Li, Milano, Randy J., Bignell, Graham R., Tam, Ah T., Davies, Helen, Stevenson, Jesse A., Barthorpe, Syd, Lutz, Stephen R., Kogera, Fiona, Lawrence, Karl, McLaren-Douglas, Anne, Mitropoulos, Xeni, Mironenko, Tatiana, Thi, Helen, Richardson, Laura, Zhou, Wenjun, Jewitt, Frances, Zhang, Tinghu, O’Brien, Patrick, Boisvert, Jessica L., Price, Stacey, Hur, Wooyoung, Yang, Wanjuan, Deng, Xianming, Butler, Adam, Choi, Hwan Geun, Chang, Jae Won, Baselga, Jose, Stamenkovic, Ivan, Engelman, Jeffrey A., Sharma, Sreenath V., Delattre, Olivier, Saez-Rodriguez, Julio, Gray, Nathanael S., Settleman, Jeffrey, Futreal, P. Andrew, Haber, Daniel A., Stratton, Michael R., Ramaswamy, Sridhar, McDermott, Ultan, Benes, Cyril H.
Publicado em 2012