Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

Activating BRAF kinase mutations arise in about 7% of all human tumors, and pre-clinical studies have validated the RAF-MEK-ERK signaling cascade as a potentially important therapeutic target in this setting. Selective RAF kinase inhibitors are currently undergoing clinical development, and based on...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Montagut, Clara, Sharma, Sreenath V., Shioda, Toshi, McDermott, Ultan, Ulman, Matthew, Ulkus, Lindsey E., Dias-Santagata, Dora, Stubbs, Hannah, Lee, Diana Y., Singh, Anurag, Drew, Lisa, Haber, Daniel A., Settleman, Jeffrey
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692356/
https://ncbi.nlm.nih.gov/pubmed/18559533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6787
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia