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Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors
Here, we applied optoRAF, an optogenetic tool for light-controlled clustering and activation of RAF proteins that mimics the natural occurring RAS-mediated dimerization. This versatile tool allows studying the effect on BRAF and CRAF homodimer- as well as heterodimer-induced RAF signaling. Vemurafen...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4812324/ https://ncbi.nlm.nih.gov/pubmed/27025703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23713 |
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