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Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas

Astrocytomas are the most common type of brain tumors in children. Activated BRAF protein kinase mutations are characteristic of pediatric astrocytomas with KIAA1549-BRAF fusion genes typifying low-grade astrocytomas and (V600E)BRAF alterations characterizing distinct or higher-grade tumors. Recentl...

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Detalhes bibliográficos
Main Authors: Sievert, Angela J., Lang, Shih-Shan, Boucher, Katie L., Madsen, Peter J., Slaunwhite, Erin, Choudhari, Namrata, Kellet, Meghan, Storm, Phillip B., Resnick, Adam C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625308/
https://ncbi.nlm.nih.gov/pubmed/23533272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219232110
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