LGG-57. FUNCTIONAL CHARACTERIZATION AND EFFECTIVE TARGETING OF NRF1-BRAF AND ATG7-RAF1 FUSIONS IDENTIFIED IN ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA PATIENTS WITHOUT BRAF p.V600E MUTATION

Pleomorphic xanthoastrocytoma (PXA) is a type of astrocytic glial neoplasm classified as WHO grade II and anaplastic PXA as WHO grade III. These tumors are known to commonly harbor BRAF (p.V600E, c.1799T>A) mutation leading to dysregulation of mitogen-activated protein kinase (MAPK) pathway. Usin...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Sonawane, Poonam, Diviney, Patrick, Phillips, Joanna, Jain, Payal, Storm, Phillip, Resnick, Adam, Waanders, Angela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012202/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.397
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