Ligand-dependent PDGF receptor-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGF receptor kinase inhibitors

Platelet-derived growth factor receptors (PDGFR) and their ligands play critical roles in several human malignancies. Sunitinib is a clinically-approved multi-targeted tyrosine kinase inhibitor which inhibits VEGFR, c-KIT, and PDGFR, and has demonstrated clinical activity in various solid tumors. Ac...

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Auteurs principaux: McDermott, Ultan, Ames, Rachel Y., Iafrate, A. John, Maheswaran, Shyamala, Stubbs, Hannah, Greninger, Patricia, McCutcheon, Kaitlin, Milano, Randy, Tam, Angela, Lee, Diana Y., Lucien, Laury, Brannigan, Brian W., Ulkus, Lindsey E., Ma, Xiao-Jun, Erlander, Mark G., Haber, Daniel A., Sharma, Sreenath V., Settleman, Jeffrey
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676215/
https://ncbi.nlm.nih.gov/pubmed/19366796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4327
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