Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

Kinase inhibitors constitute an important new class of cancer drugs, whose selective efficacy is largely determined by underlying tumor cell genetics. We established a high-throughput platform to profile 500 cell lines derived from diverse epithelial cancers for sensitivity to 14 kinase inhibitors....

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Hlavní autoři: McDermott, Ultan, Sharma, Sreenath V., Dowell, Lori, Greninger, Patricia, Montagut, Clara, Lamb, Jennifer, Archibald, Heidi, Raudales, Raul, Tam, Angela, Lee, Diana, Rothenberg, S. Michael, Supko, Jeffrey G., Sordella, Raffaella, Ulkus, Lindsey E., Iafrate, A. John, Maheswaran, Shyamala, Njauw, Ching Ni, Tsao, Hensin, Drew, Lisa, Hanke, Jeff H., Ma, Xiao-Jun, Erlander, Mark G., Gray, Nathanael S., Haber, Daniel A., Settleman, Jeffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148401/
https://ncbi.nlm.nih.gov/pubmed/18077425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707498104
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