Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

Kinase inhibitors constitute an important new class of cancer drugs, whose selective efficacy is largely determined by underlying tumor cell genetics. We established a high-throughput platform to profile 500 cell lines derived from diverse epithelial cancers for sensitivity to 14 kinase inhibitors....

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Detalhes bibliográficos
Main Authors: McDermott, Ultan, Sharma, Sreenath V., Dowell, Lori, Greninger, Patricia, Montagut, Clara, Lamb, Jennifer, Archibald, Heidi, Raudales, Raul, Tam, Angela, Lee, Diana, Rothenberg, S. Michael, Supko, Jeffrey G., Sordella, Raffaella, Ulkus, Lindsey E., Iafrate, A. John, Maheswaran, Shyamala, Njauw, Ching Ni, Tsao, Hensin, Drew, Lisa, Hanke, Jeff H., Ma, Xiao-Jun, Erlander, Mark G., Gray, Nathanael S., Haber, Daniel A., Settleman, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148401/
https://ncbi.nlm.nih.gov/pubmed/18077425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707498104
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