Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: The Notch signaling pathway is required for the expansion of undifferentiated pancreatic progenitor cells during embryonic development and has been implicated in the progression of pancreatic ductal adenocarcinoma (PDAC). The interaction of Notch ligands with their receptors p...

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Detalhes bibliográficos
Main Authors: Plentz, Ruben, Park, Ji-Sun, Rhim, Andrew D., Abravanel, Daniel, Hezel, Aram F., Sharma, Sreenath V., Gurumurthy, Sushma, Deshpande, Vikram, Kenific, Candia, Settleman, Jeffrey, Majumder, Pradip K., Stanger, Ben Z., Bardeesy, Nabeel
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675892/
https://ncbi.nlm.nih.gov/pubmed/19208345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.01.008
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