Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

LKB1 is a key regulator of energy homeostasis through the activation of AMP-activated protein kinase (AMPK) and is functionally linked to vascular development, cell polarity, and tumor suppression. In humans, germ line LKB1 loss-of-function mutations cause Peutz-Jeghers syndrome (PJS), which is char...

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Main Authors: Hezel, Aram F., Gurumurthy, Sushma, Granot, Zvi, Swisa, Avital, Chu, Gerry C., Bailey, Gerald, Dor, Yuval, Bardeesy, Nabeel, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268441/
https://ncbi.nlm.nih.gov/pubmed/18227155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01621-07
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