LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function

Pancreatic β cells, organized in the islets of Langerhans, sense glucose and secrete appropriate amounts of insulin. We have studied the roles of LKB1, a conserved kinase implicated in the control of cell polarity and energy metabolism, in adult β cells. LKB1-deficient β cells show a dramatic increa...

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Detalhes bibliográficos
Main Authors: Granot, Zvi, Swisa, Avital, Magenheim, Judith, Stolovich-Rain, Miri, Fujimoto, Wakako, Manduchi, Elisabetta, Miki, Takashi, Lennerz, Jochen K., Stoeckert, Christian J., Meyuhas, Oded, Seino, Susumu, Permutt, M. Alan, Piwnica-Worms, Helen, Bardeesy, Nabeel, Dor, Yuval
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790403/
https://ncbi.nlm.nih.gov/pubmed/19808022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.08.010
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