Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects

The tumor suppressor liver kinase B1 (LKB1) is an important regulator of pancreatic β cell biology. LKB1-dependent phosphorylation of distinct AMPK (adenosine monophosphate-activated protein kinase) family members determines proper β cell polarity and restricts β cell size, total β cell mass, and gl...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Swisa, Avital, Granot, Zvi, Tamarina, Natalia, Sayers, Sophie, Bardeesy, Nabeel, Philipson, Louis, Hodson, David J., Wikstrom, Jakob D., Rutter, Guy A., Leibowitz, Gil, Glaser, Benjamin, Dor, Yuval
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543653/
https://ncbi.nlm.nih.gov/pubmed/26139601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.639237
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