AMPK Regulates ER Morphology and Function in Stressed Pancreatic β-Cells via Phosphorylation of DRP1

Experimental lipotoxicity constitutes a model for β-cell demise induced by metabolic stress in obesity and type 2 diabetes. Fatty acid excess induces endoplasmic reticulum (ER) stress, which is accompanied by ER morphological changes whose mechanisms and relevance are unknown. We found that the GTPa...

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Dettagli Bibliografici
Pubblicato in:Mol Endocrinol
Autori principali: Wikstrom, Jakob D., Israeli, Tal, Bachar-Wikstrom, Etty, Swisa, Avital, Ariav, Yafa, Waiss, Meytal, Kaganovich, Daniel, Dor, Yuval, Cerasi, Erol, Leibowitz, Gil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2013
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427881/
https://ncbi.nlm.nih.gov/pubmed/23979843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1109
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