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LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
Lkb1 is a central regulator of cell polarity and energy metabolism through its capacity to activate the AMPK-related family of protein kinases. Germ line inactivating mutation of Lkb1 leads to Peutz-Jeghers syndrome, which is characterized by benign hamartomas and a susceptibility to malignant epith...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3739055/ https://ncbi.nlm.nih.gov/pubmed/18172296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-3225 |
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