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LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis

Lkb1 is a central regulator of cell polarity and energy metabolism through its capacity to activate the AMPK-related family of protein kinases. Germ line inactivating mutation of Lkb1 leads to Peutz-Jeghers syndrome, which is characterized by benign hamartomas and a susceptibility to malignant epith...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Gurumurthy, Sushma, Hezel, Aram F., Sahin, Ergun, Berger, Justin H., Bosenberg, Marcus W., Bardeesy, Nabeel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739055/
https://ncbi.nlm.nih.gov/pubmed/18172296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-3225
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