LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases

BACKGROUND: Live kinase B1 (LKB1) is a tumor suppressor that is mutated in Peutz-Jeghers syndrome (PJS) and a variety of cancers. Lkb1 encodes serine-threonine kinase (STK) 11 that activates AMP-activated protein kinase (AMPK) and its 13 superfamily members, regulating multiple biological processes,...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Zhang, Yanghe, Meng, Qingfei, Sun, Qianhui, Xu, Zhi-Xiang, Zhou, Honglan, Wang, Yishu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7753952/
https://ncbi.nlm.nih.gov/pubmed/33278637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101131
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