Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling

The LKB1/AMPK pathway plays a major role in cellular homeostasis and tumor suppression. Down-regulation of LKB1/AMPK occurs in several human cancers and has been implicated in metabolic diseases. However, the precise upstream regulation of LKB1-AMPK pathway is largely unknown. Here, we report that A...

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Publicado en:Nat Commun
Autores principales: Li, Nan, Wang, Yifan, Neri, Shinya, Zhen, Yuanli, Fong, Lon Wolf R., Qiao, Yawei, Li, Xu, Chen, Zhen, Stephan, Clifford, Deng, Weiye, Ye, Rui, Jiang, Wen, Zhang, Shuxing, Yu, Yonghao, Hung, Mien-Chie, Chen, Junjie, Lin, Steven H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761205/
https://ncbi.nlm.nih.gov/pubmed/31554794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12377-1
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