The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

PI3K/Akt signaling is activated in cancers and governs tumor initiation and progression, but how Akt is activated under diverse stresses is poorly understood. Here we identify AMPK as an essential regulator for Akt activation by various stresses. Surprisingly, AMPK is also activated by growth factor...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Han, Fei, Li, Chien-Feng, Cai, Zhen, Zhang, Xian, Jin, Guoxiang, Zhang, Wei-Na, Xu, Chuan, Wang, Chi-Yun, Morrow, John, Zhang, Shuxing, Xu, Dazhi, Wang, Guihua, Lin, Hui-Kuan
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226490/
https://ncbi.nlm.nih.gov/pubmed/30413706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07188-9
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