Cycles of Ubiquitination and Deubiquitination Critically Regulate Growth Factor-Mediated Activation of Akt Signaling

K63-linked ubiquitination of Akt is a posttranslational modification that plays a critical role in growth factor-mediated membrane recruitment and activation of Akt. Although E3 ligases involved in growth factor-induced Akt ubiquitination have been defined, the deubiquitinating enzyme (DUB) that tri...

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Bibliografiske detaljer
Main Authors: Yang, Wei-Lei, Jin, Guoxiang, Li, Chien-Feng, Jeong, Yun Seong, Moten, Asad, Xu, Dazhi, Feng, Zizhen, Chen, Wei, Cai, Zhen, Darnay, Bryant, Gu, Wei, Lin, Hui-Kuan
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862898/
https://ncbi.nlm.nih.gov/pubmed/23300340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003197
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