Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression

Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell cycle progression, senescence, metabolism, cancer progression and metastasis. In the present study, we identified a specific Skp2 inhibitor using high-throughput in silico screening of large and diverse chemi...

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Bibliographic Details
Main Authors: Chan, Chia-Hsin, Morrow, John Kenneth, Li, Chien-Feng, Gao, Yuan, Jin, Guoxiang, Moten, Asad, Stagg, Loren J., Ladbury, John E., Cai, Zhen, Xu, Dazhi, Logothetis, Christopher J., Hung, Mien-Chie, Zhang, Shuxing, Lin, Hui-Kuan
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845452/
https://ncbi.nlm.nih.gov/pubmed/23911321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.048
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