Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression

Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell cycle progression, senescence, metabolism, cancer progression and metastasis. In the present study, we identified a specific Skp2 inhibitor using high-throughput in silico screening of large and diverse chemi...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Chan, Chia-Hsin, Morrow, John Kenneth, Li, Chien-Feng, Gao, Yuan, Jin, Guoxiang, Moten, Asad, Stagg, Loren J., Ladbury, John E., Cai, Zhen, Xu, Dazhi, Logothetis, Christopher J., Hung, Mien-Chie, Zhang, Shuxing, Lin, Hui-Kuan
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845452/
https://ncbi.nlm.nih.gov/pubmed/23911321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.048
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars