The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis

Akt kinase plays a central role in cell growth, metabolism and tumorigenesis. Although TRAF6 E3 ligase orchestrates IGF-1-mediated Akt ubiquitination and activation, it is unclear whether TRAF6 is involved in Akt activation by other growth factor receptors as well. Here we show that Akt ubiquitinati...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chan, Chia-Hsin, Li, Chien-Feng, Yang, Wei-Lei, Gao, Yuan, Lee, Szu-Wei, Feng, Zizhen, Huang, Hsuan-Ying, Tsai, Kelvin K. C., Flores, Leo G., Shao, Yiping, Hazle, John D., Yu, Dihua, Wei, Wenyi, Sarbassov, Dos, Hung, Mien-Chie, Nakayama, Keiichi I., Lin, Hui-Kuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586339/
https://ncbi.nlm.nih.gov/pubmed/22632973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.065
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados