The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis

Akt kinase plays a central role in cell growth, metabolism and tumorigenesis. Although TRAF6 E3 ligase orchestrates IGF-1-mediated Akt ubiquitination and activation, it is unclear whether TRAF6 is involved in Akt activation by other growth factor receptors as well. Here we show that Akt ubiquitinati...

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Bibliographische Detailangaben
Hauptverfasser: Chan, Chia-Hsin, Li, Chien-Feng, Yang, Wei-Lei, Gao, Yuan, Lee, Szu-Wei, Feng, Zizhen, Huang, Hsuan-Ying, Tsai, Kelvin K. C., Flores, Leo G., Shao, Yiping, Hazle, John D., Yu, Dihua, Wei, Wenyi, Sarbassov, Dos, Hung, Mien-Chie, Nakayama, Keiichi I., Lin, Hui-Kuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586339/
https://ncbi.nlm.nih.gov/pubmed/22632973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.065
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