Loading...

SCF ubiquitin ligase targeted therapies

The recent clinical successes of inhibitors of the proteasome for the treatment of cancer have highlighted the therapeutic potential of this protein degradation system. Proteasome inhibitors prevent the degradation of numerous proteins, so increased specificity could be achieved by inhibiting the co...

Full description

Saved in:
Bibliographic Details
Published in:Nat Rev Drug Discov
Main Authors: Skaar, Jeffrey R., Pagan, Julia K., Pagano, Michele
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410837/
https://ncbi.nlm.nih.gov/pubmed/25394868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4432
Tags: Add Tag
No Tags, Be the first to tag this record!