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SCF ubiquitin ligase targeted therapies

The recent clinical successes of inhibitors of the proteasome for the treatment of cancer have highlighted the therapeutic potential of this protein degradation system. Proteasome inhibitors prevent the degradation of numerous proteins, so increased specificity could be achieved by inhibiting the co...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Rev Drug Discov
Prif Awduron: Skaar, Jeffrey R., Pagan, Julia K., Pagano, Michele
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410837/
https://ncbi.nlm.nih.gov/pubmed/25394868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4432
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