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SCF ubiquitin ligase targeted therapies
The recent clinical successes of inhibitors of the proteasome for the treatment of cancer have highlighted the therapeutic potential of this protein degradation system. Proteasome inhibitors prevent the degradation of numerous proteins, so increased specificity could be achieved by inhibiting the co...
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| Published in: | Nat Rev Drug Discov |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4410837/ https://ncbi.nlm.nih.gov/pubmed/25394868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4432 |
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