PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis

BACKGROUND: Phosphatase and tensin homolog (PTEN) is an important tumor suppressor gene, and its encoded protein has activities of both a protein phosphatase and a lipid phosphatase. However, the substitution effect of protein phosphatase activity remains unclear. PI3K/Akt is the most common pathway...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Xu, Wenting, Yang, Zhen, Xie, Chuan, Zhu, Yin, Shu, Xu, Zhang, Zhe, Li, Nianshuang, Chai, Na, Zhang, Song, Wu, Kaichun, Nie, Yongzhan, Lu, Nonghua
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104022/
https://ncbi.nlm.nih.gov/pubmed/30134988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0795-2
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