Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway

Phosphorylation of PTEN at residues Ser380/Thr382/383 leads to loss of phosphatase activity and tumor suppressor function. Here, we found that phosphorylation of PTEN at residues Ser380/Thr382/383 was increased with gastric carcinogenesis, and more importantly, Helicobacter pylori was a trigger of t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yang, Zhen, Xie, Chuan, Xu, Wenting, Liu, Gongmeizi, Cao, Ximei, Li, Wei, Chen, Jiang, Zhu, Yin, Luo, Shiwen, Luo, Zhijun, Lu, Nonghua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741650/
https://ncbi.nlm.nih.gov/pubmed/26376616
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