Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis

Loss of tumor suppressor liver kinase B1 (LKB1) promotes cancer cell proliferation but also leads to decreased metabolic plasticity in dealing with energy crises. Autophagy is a protective process involving self-cannibalization to maintain cellular energy homeostasis during nutrient deprivation. We...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Bhatt, Vrushank, Khayati, Khoosheh, Hu, Zhixian Sherrie, Lee, Amy, Kamran, Wali, Su, Xiaoyang, Guo, Jessie Yanxiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2019
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362813/
https://ncbi.nlm.nih.gov/pubmed/30692209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.320481.118
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