Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

Autophagy is a catabolic pathway used by cells to support metabolism in response to starvation and to clear damaged proteins and organelles in response to stress. We report here that expression of a H-ras(V12) or K-ras(V12) oncogene up-regulates basal autophagy, which is required for tumor cell surv...

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Bibliografiske detaljer
Main Authors: Guo, Jessie Yanxiang, Chen, Hsin-Yi, Mathew, Robin, Fan, Jing, Strohecker, Anne M., Karsli-Uzunbas, Gizem, Kamphorst, Jurre J., Chen, Guanghua, Lemons, Johanna M.S., Karantza, Vassiliki, Coller, Hilary A., DiPaola, Robert S., Gelinas, Celine, Rabinowitz, Joshua D., White, Eileen
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2011
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049287/
https://ncbi.nlm.nih.gov/pubmed/21317241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2016311
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