Autophagy Suppresses Tumorigenesis Through Elimination of p62

Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism. While tumor cells utilize autophagy to survive metabolic stress, autophagy also mitigates the resulting cellular damage that may limit...

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Detalhes bibliográficos
Main Authors: Mathew, Robin, Karp, Cristina, Beaudoin, Brian, Vuong, Nhan, Chen, Guanghua, Chen, Hsin-Yi, Bray, Kevin, Reddy, Anupama, Bhanot, Gyan, Gelinas, Celine, DiPaola, Robert S., Karantza-Wadsworth, Vassiliki, White, Eileen
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802318/
https://ncbi.nlm.nih.gov/pubmed/19524509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.048
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