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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857533/ https://ncbi.nlm.nih.gov/pubmed/16843265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.06.001 |
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