Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by...

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Hlavní autoři: Degenhardt, Kurt, Mathew, Robin, Beaudoin, Brian, Bray, Kevin, Anderson, Diana, Chen, Guanghua, Mukherjee, Chandreyee, Shi, Yufang, Gélinas, Céline, Fan, Yongjun, Nelson, Deirdre A., Jin, Shengkan, White, Eileen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857533/
https://ncbi.nlm.nih.gov/pubmed/16843265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.06.001
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