Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Degenhardt, Kurt, Mathew, Robin, Beaudoin, Brian, Bray, Kevin, Anderson, Diana, Chen, Guanghua, Mukherjee, Chandreyee, Shi, Yufang, Gélinas, Céline, Fan, Yongjun, Nelson, Deirdre A., Jin, Shengkan, White, Eileen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857533/
https://ncbi.nlm.nih.gov/pubmed/16843265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.06.001
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi