Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

Macroautophagy (autophagy hereafter) degrades and recycles proteins and organelles to support metabolism and survival in starvation. Oncogenic Ras up-regulates autophagy, and Ras-transformed cell lines require autophagy for mitochondrial function, stress survival, and engrafted tumor growth. Here, t...

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Hlavní autoři: Guo, Jessie Yanxiang, Karsli-Uzunbas, Gizem, Mathew, Robin, Aisner, Seena C., Kamphorst, Jurre J., Strohecker, Anne M., Chen, Guanghua, Price, Sandy, Lu, Wenyun, Teng, Xin, Snyder, Eric, Santanam, Urmila, DiPaola, Robert S., Jacks, Tyler, Rabinowitz, Joshua D., White, Eileen
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2013
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713426/
https://ncbi.nlm.nih.gov/pubmed/23824538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.219642.113
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