Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

Macroautophagy (autophagy hereafter) degrades and recycles proteins and organelles to support metabolism and survival in starvation. Oncogenic Ras up-regulates autophagy, and Ras-transformed cell lines require autophagy for mitochondrial function, stress survival, and engrafted tumor growth. Here, t...

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Bibliografiska uppgifter
Huvudupphovsmän: Guo, Jessie Yanxiang, Karsli-Uzunbas, Gizem, Mathew, Robin, Aisner, Seena C., Kamphorst, Jurre J., Strohecker, Anne M., Chen, Guanghua, Price, Sandy, Lu, Wenyun, Teng, Xin, Snyder, Eric, Santanam, Urmila, DiPaola, Robert S., Jacks, Tyler, Rabinowitz, Joshua D., White, Eileen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2013
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713426/
https://ncbi.nlm.nih.gov/pubmed/23824538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.219642.113
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